Everything about Neuropilin totally explained
Neuropilin is a
protein receptor active in
neurons.
Overview
There are two forms of Neuropilins,
NRP-1 and
NRP-2. They are transmembrane glycoproteins, and predominantly
co-receptors for another class of proteins known as
Semaphorins. Of the Semaphorins, NRP-1 and NRP-2 are specically receptors for Class-3 Semaphorins, which, amongst many things, are responsible for
axon guidance during the development of the
nervous system in
vertebrates.
Neuropilins work as co-receptors as they've a very small
cytoplasmic domain and thus rely upon other molecules to transduce their signals across a
cell membrane, normally
Plexins. Neuropilins generally work as
dimers and different combinations have different affinities for molecules. For example, NRP-1 homodimers have high affinity for Sema-3A, whilst NRP-2 homodimers have high affinity for Sema-3F.
Another ligand for neuropilins is
VEGF, a growth hormone involved in the regulation of
angiogenesis.
Further Information
Get more info on 'Neuropilin'.
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